Effects of Taking Chemotherapy Drugs (Hands and Foot Syndrome)
Hand-Foot Syndrome (HFS)—also known as palmar-plantar erythrodysesthesia (PPE)—is a common side effect of certain chemotherapy drugs. It primarily affects the palms of the hands and soles of the feet, causing a range of symptoms due to drug leakage into the capillaries of the skin.
Chemotherapy Drugs Commonly Associated with HFS
- Capecitabine (Xeloda)
- 5-Fluorouracil (5-FU)
- Liposomal doxorubicin (Doxil)
- Cytarabine
- Docetaxel
- Sorafenib and sunitinib (targeted therapies)
Symptoms of Hand-Foot Syndrome
Symptoms usually develop gradually and may worsen with continued treatment:
Mild (Grade 1):
- Redness (erythema)
- Mild swelling
- Tingling or numbness
Moderate (Grade 2):
- Painful redness
- Peeling or blistering of skin
- Discomfort affecting daily activities
Severe (Grade 3):
- Cracked, ulcerated skin
- Severe pain
- Difficulty walking or using hands
Pathophysiology (Why It Happens)
The exact mechanism isn’t fully understood, but it’s thought that:
- Chemotherapy drugs leak from capillaries in hands and feet.
- Friction and pressure (e.g., walking, gripping) cause more drug accumulation.
- This leads to inflammation and skin cell damage.
Preventative Steps
- Avoid hot water (e.g., long hot showers, dishwashing)
- Reduce pressure/friction (avoid tight shoes, repetitive motion)
- Use cold packs to decrease blood flow to extremities during treatment
- Keep hands and feet moisturized (use urea or lanolin-based creams)
We are independent prescribers able to prescribe any medication from the BNF relevant to the lower limb, foot and ankle.
Are you suffering from any hand or foot condition? At The Chelsea Clinic, we can help. One of our podiatrists can assist and then recommend what treatments are best to get you back on track. Podiatrist South Kensington
Schedule an appointment here or you may call us at +44 (0) 207 101 4000.
We hope you have a feetastic day!
-The Chelsea Clinic and Team
Book Here
