Palmoplantar keratoderma (PPK)

Palmoplantar keratoderma (PPK) is a group of skin conditions characterized by thickening of the skin on the palms of the hands and the soles of the feet.  This condition can be inherited or acquired and can also vary in severity.

Types and Causes

1. Inherited (Genetic) PPK
   • Autosomal Dominant.  Such as in conditions like keratoderma climactericum (occurring during menopause) or palmar-plantar keratoderma linked to other genetic syndromes.
   • Autosomal Recessive.  Like Naxos syndrome or papillon-lefèvre syndrome, which may also involve other symptoms such as heart problems or dental issues.
2. Acquired PPK
   • Can be associated with other conditions such as:
     • Chronic irritation.  Prolonged exposure to chemicals or friction.
     • Psoriasis.  A chronic autoimmune condition that can cause thickened skin.
     • Systemic diseases.  Such as hyperkeratosis related to certain cancers or metabolic disorders.

Symptoms

• Thickened, rough skin on palms and soles
• Potential pain or discomfort, and also
• Sometimes accompanied by blisters or fissures

Treatment

• Topical Treatments.  Such as keratolytic agents (e.g., salicylic acid) to help soften and remove thickened skin.
• Oral Medications.  For associated conditions like psoriasis or if topical treatments are ineffective.
• Avoiding Irritants.  In cases of acquired PPK, minimizing exposure to irritants or friction can help manage symptoms.

Management

• Regular moisturizing to keep the skin hydrated.
• Protective footwear and also gloves to reduce friction and irritation.
• Regular follow-ups with a healthcare professional for personalized treatment and management.

We are independent prescribers able to prescribe any medication from the BNF relevant to the lower limb, foot and ankle.

Are you suffering from any hand or foot condition?  At The Chelsea Clinic, we can help.  One of our podiatrist can assist and then recommend what treatments are best to get you back on track. Podiatrist South Kensington

Schedule an appointment here or you may call us at +44 (0) 207 101 4000. 

We hope you have a feetastic day!

-The Chelsea Clinic and Team

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